The next is a abstract of some latest research on COVID–19. They embody analysis that warrants additional examine to corroborate the findings and that has but to be licensed by peer evaluation.
Larger estrogen ranges tied to decrease COVID demise threat
A brand new examine strengthens suspicions that the feminine hormone estrogen protects towards demise from COVID–19.
Researchers in Sweden studied 14,685 older ladies with COVID–19, all of whom have been previous menopause, throughout which estrogen ranges decline dramatically.
Seventeen % have been taking estrogen dietary supplements to alleviate menopausal signs.
After adjusting for different threat elements, ladies getting additional estrogen had a 53% decrease threat of dying from COVID–19 in comparison with untreated ladies, the researchers reported on Monday in BMJ Open.
Observational research resembling this one can’t show larger estrogen ranges are protecting. Moreover, the ladies have been contaminated earlier than vaccines have been accessible, stated Dr. Malin Sund of Umea College.
“Vaccination has clearly been proven to guard from COVID–19 associated mortality and the potential added worth from estrogen (in vaccinated ladies) can’t be estimated from this information,” Sund stated. The concept estrogen may be protecting in hospitalized COVID–19 sufferers is now being examined extra rigorously in a randomized managed trial at Tulane College.
Antacid exhibits promise towards COVID–19 signs
In non-hospitalized, unvaccinated adults with mild-to-moderate COVID–19, remedy with a excessive dose of the antacid drug famotidine helped pace decision of signs and irritation in a small randomized managed trial.
Roughly half of these within the 55-patient trial took famotidine – the primary ingredient in Johnson & Johnson’s extensively used over-the-counter Pepsid heartburn drug – thrice a day for 2 weeks. The others took a dummy capsule. Sufferers within the famotidine group had quicker decision of 14 of 16 signs assessed within the examine, together with lack of scent and style, issue respiratory and stomach ache.
Famotidine remedy additionally led to quicker enhancements in markers of irritation with none detrimental results on sufferers’ immune responses, the researchers reported within the journal Intestine. A few third of the examine’s contributors have been Black and 1 / 4 Hispanic.
“We hope that the information we’re sharing with this examine information future trials which can be obligatory to verify famotidine as a remedy for sufferers with COVID–19,” examine chief Dr. Tobias Janowitz of Northwell Well being and Chilly Spring Harbor Laboratory stated in a information launch.
U.S. could have overestimated COVID–19 hospitalizations
U.S. statistics possible overestimate what number of sufferers have been hospitalized for COVID–19, in keeping with a brand new examine.
At 60 hospitals close to Boston, Pittsburgh and Chicago, researchers manually reviewed the charts of a random pattern of 1,123 sufferers with confirmed coronavirus infections hospitalized between March 2020 and August 2021.
Roughly 1-in-4 sufferers “truly have been admitted for a special drawback and shouldn’t have been included” in information analytics calculations of the severity of COVID–19, stated Dr. Shawn Murphy of Massachusetts Normal Hospital in Boston.
Sufferers have been extra more likely to have been admitted particularly for COVID–19 when native an infection charges have been excessive, his staff reported on Tuesday on medRxiv forward of peer evaluation. When an infection charges have been low final summer time, as much as half the sufferers have been hospitalized for different causes, with SARS-CoV-2 an infection discovered coincidentally on necessary testing.
The researchers have been in a position to determine indicators in sufferers’ charts that admissions have been truly because of COVID–19, resembling whether or not medical doctors ordered lab exams associated to irritation.
“This examine highlights an essential weak spot in COVID–19 reporting, which could have implications on intensive care utilization, price evaluation, useful resource planning, and analysis,” stated Jeffrey Klann, additionally of Mass Normal. Including the recognized indicators to information analytics software program “may assist mitigate these issues.”
—Reporting by Nancy Lapid and Megan Brooks; Modifying by Invoice Berkrot